Clinical impact of circulating microRNA-21-5p on the severity of coronary artery disease

Background and Aims : To explore the clinical value of circulatory miR-21-5p as an early non-invasive biomarker for coronary artery disease (CAD) patients degree stenosis.Methods: Invasive angiographically confirmed 87 multivessel lesion CAD, 73 double vessel 35 single CAD healthy subjects were enrolled in this study.Results: Circulatory plasma expressions gradually significantly elevated single, double, multi-vessel occluded compared with participants (p<0.001). Muti-vessel (AUC: 0.962), 0.953) (AUC:0.947) able to differentiated from remarkable specificity sensitivity. Plasma concentrations geriatric (65-85 years) prominently higher younger (25-45 years), (46-64 age groups subjects(p<0.001).Conclusions: Elevated levels may be used a potential detection categorized severity stenosis levels. stenosis. Methods: study. Results: subjects(p<0.001). Conclusions: